Gibt es Doppelblind-Tierversuchsstudien bei Impfungen?

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2 Antworten

Wenn ich auf der Suche nach Doppelblind-Impfstudien in die Suchmaske der medizinischen Datenbanken (z.B. www.dimdi.de) die entsprechenden Begriffe controlled study und vaccination eingebe, erhalte ich 23271 Treffer ...

o0Alea0o 28.12.2012, 18:10

Es gibt durchaus auch (nicht-der-Ethik-entsprechende(?) Doppelblindstudien über Impfungen?

D.h. selbst die Impfbefürworter haben mit dem Argument: "Es gäbe keine, weil es nicht geht..." eher eine Halbwahrheit, während die Impfgegner total die Realität ignorieren?

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Hier hast du eine Studie:

A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions

Author(s): van Steenwijk, PJD (van Steenwijk, Peggy J. de Vos)2; Ramwadhdoebe, TH (Ramwadhdoebe, Tamara H.)1; Lowik, MJG (Lowik, Margriet J. G.)2; van der Minne, CE (van der Minne, Caroline E.)1; Berends-van der Meer, DMA (Berends-van der Meer, Dorien M. A.)2; Fathers, LM (Fathers, Lorraine M.)3; Valentijn, ARPM (Valentijn, A. Rob P. M.)3; Oostendorp, J (Oostendorp, Jaap)3; Fleuren, GJ (Fleuren, Gert Jan)4; Hellebrekers, BWJ (Hellebrekers, Bart W. J.)5; Welters, MJP (Welters, Marij J. P.)1; van Poelgeest, MI (van Poelgeest, Mariette I.)2; Melief, CJM (Melief, Cornelis J. M.)6,7; Kenter, GG (Kenter, Gemma G.)2; van der Burg, SH (van der Burg, Sjoerd H.)1

Source: CANCER IMMUNOLOGY IMMUNOTHERAPY Volume: 61 Issue: 9 Pages: 1485-1492 DOI: 10.1007/s00262-012-1292-7 Published: SEP 2012

Abstract: The aim of this study was to investigate the capacity of an HPV16 E6/E7 synthetic overlapping long-peptide vaccine to stimulate the HPV16-specific T-cell response, to enhance the infiltration of HPV16-specific type 1 T cells into the lesions of patients with HPV16+ high-grade cervical squamous intraepithelial lesion (HSIL) and HPV clearance. This was a placebo-controlled randomized phase II study in patients with HPV16-positive HSIL. HPV16-specific T-cell responses were determined pre- and post-vaccination by ELISPOT, proliferation assay and cytokine assays in PBMC and HSIL-infiltrating lymphocytes, and delayed-type hypersensitivity skin tests. Motivational problems of this patient group to postpone treatment of their premalignant lesions affected the inclusion rates and caused the study to stop prematurely.

No conclusions could be drawn on vaccine-enhanced T-cell infiltration of the lesion, and there was no HPV clearance at the time of LEEP excision. Thus, vaccination of HSIL patients results in increased HPV16-specific T-cell immunity. Further development of this type of treatment relies on the ability to motivate patients and in the reduction in the side effects.

Den englischen Volltext können sich Wissenschaftler an ihren Universitäten besorgen.

bruno84 20.10.2012, 21:04

Further development of this type of treatment relies on the ability to motivate patients and in the reduction in the side effects.

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